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    放大字體  縮小字體 發布日期:2015-07-17  瀏覽次數:538
    核心提示:2014年3月3日訊 /生物谷BIOON/ --最近英國倫敦Great Ormond Street Hospital的醫生計劃利用從人脂肪組織中提取的干細胞來體外誘導
     2014年3月3日訊 /生物谷BIOON/ --最近英國倫敦Great Ormond Street Hospital的醫生計劃利用從人脂肪組織中提取的干細胞來體外誘導培育耳朵、鼻子等器官用于器官移植。這一技術已經發表在Nanomedicine雜志上,他們將這一技術成為突破性成果。研究人員希望將這一技術應用于治療小耳癥等疾病。

    該項目的研究人員介紹說,這一技術主要是提取患者的一部分脂肪組織并從中獲取其干細胞進行體外培養。同時通過向這些干細胞中加入一個類耳型支架使得干細胞能夠附著在上面生長,并最終形成一個類似耳朵形狀的器官。不過來自倫敦大學的Prof Martin Birchall同時認為這一技術還需要通過相關安全性測試才能最終在臨床上獲得普及應用。(生物谷Bioon.com)


    Doctors at Great Ormond Street Hospital in London are aiming to reconstruct people's faces with stem cells taken from their fat.

    The team has grown cartilage in the laboratory and believe it could be used to rebuild ears and noses.

    They say the technique, published in the journal Nanomedicine, could revolutionise care.

    Experts said there was some way to go, but it had the potential to be "transformative".

    The doctors want to treat conditions like microtia, that results in the ear failing to develop properly and can be missing or malformed.

    At the moment, children have cartilage taken from their ribs, which is then delicately sculpted by surgeons to resemble an ear and implanted into the child.

    It requires multiple operations, leaves permanent scarring on the chest and the rib cartilage never recovers.

    From fat

    The team envisage an alternative - a tiny sample of fat would be taken from the child and stem cells would be extracted and grown from it.

    An ear-shaped "scaffold" would be placed in the stem cell broth so the cells would take on the desired shape and structure. And chemicals would be used to persuade the stem cells to transform into cartilage cells.

    This could then be implanted beneath the skin to give the child an ear shape.

    The researchers have been able to create the cartilage in the scaffold, but safety testing is needed before they could be used in patients.

    One of the researchers, Dr Patrizia Ferretti, told the BBC: "It is really exciting to have the sort of cells that are not tumourogenic, that can go back into the same patient so we don't have the problem of immunosuppression and can do the job you want them to do.

    "It would be the Holy Grail to do this procedure through a single surgery, so decreasing enormously the stress for the children and having a structure that hopefully will be growing as the child grows."

    New ear

    The technique could help patients like 15-year old Samuel Clompus, who has had the reconstructive ear surgery.

    His mother, Sue, said the family welcomed the research.

    She told the BBC: "They wouldn't have needed to take the cartilage.

    "He has a scar there now and Sam said it was the most uncomfortable bit."

    The technique could be used to create cartilage for other tissues such as the nose, which can be damaged in adults after cancer surgery.

    Doctors say they could also make bone using the same starting material.

    "Obviously we are at the beginning of this, the next step will be to perfect just the choice of materials and to develop this further," said Dr Ferretti.

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